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The BCERF program on the Cancer Risks of Environmental Chemicals in the Home and Workplace closed on March 31, 2010. No further updates will be made to this web site. Please go Cornell University’s eCommons web site to access BCERF’s archived research and educational materials (http://ecommons.library.cornell.edu/handle/1813/14300).

Polyaromatic Hydrocarbons (PAHs) and Breast Cancer
Bibliography

This bibliography is provided as a service to our readers. It is compiled from the entries in the BCERF Environmental Risk Factors Bibliographic Database.

This bibliography is arranged topically. The topics include:

Review Articles on PAHs

ATSDR (1990a). ATSDR Public Health Statement: Polycyclic Aromatic Hydrocarbons (http://www.atsdr.cdc.gov/ToxProfiles/phs9020.html, cited July 9, 2001, Agency for Toxic Disease Substances Registry).

ATSDR (1990b). Toxicological profile for polycyclic aromatic hydrocarbons (Springfield, VA, Agency for Toxic Disease Substances Registry, National Technical Information Service).

ATSDR (1996). ATSDR ToxFaqs: Polycyclic Aromatic Hydrocarbons (http://www.atsdr.cdc.gov/tfacts69.html, cited July 9, 2001, Agency for Toxic Substances Disease Registry).

Mastrangelo, G., Fadda, E., and Marzia, V. (1996). Polycyclic aromatic hydrocarbons and cancer in man, Environmental Health Perspectives 104, 1166-1170.

Morris, J. J., and Seifter, E. (1992). The role of aromatic hydrocarbons in the genesis of breast cancer, Medical Hypotheses 38, 177-184.

Russo, I. H., and Russo, J. (1996). Mammary gland neoplasia in long-term rodent studies, Environmental Health Perspectives 104, 938-967.

Warshawsky, D. (1999). Polycyclic aromatic hydrocarbons in carcinogenesis, Environmental Health Perspectives 107, 317-319.

WHO (1998). Environmental Health Criteria 202, Selected Non-Heterocyclic Polycyclic Aromatic Hydrocarbons (Geneva, World Health Organization).

PAHs and Cancer Risk in Humans
   - Epidemiologic Studies

Ambrosone, C. B., Freudenheim, J. L., Graham, S., Marshall, J. R., Vena, J. E., Brasure, J. R., Laughlin, R., Nemoto, T., Michalek, A. M., Harrington, A., et al. (1995). Cytochrome P4501A1 and glutathione S-transferase (M1) genetic polymorhisms and postmenopausal breast cancer risk, Cancer Research 55, 3483-3485.

Ishibe, N., Hankinson, S. E., Colditz, G. A., Spiegelman, D., Willett, W. C., Speizer, F. E., Kelsey, K. T., and Hunter, D. J. (1998). Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study, Cancer Research 58, 667-671.

Li, D., Zhang, W., Sahin, A. A., and Hittelman, W. N. (1999). DNA adducts in normal tissue adjacent to breast cancer: A review, Cancer Detection and Prevention 23, 454-462.

Mastrangelo, G., Fadda, E., and Marzia, V. (1996). Polycyclic aromatic hydrocarbons and cancer in man, Environmental Health Perspectives 104, 1166-1170.

Petralia, S. A., Vena, J. E., Freudenheim, J. L., Dosemeci, M., Michalek, A., Goldberg, M. S., Brasure, J., and Graham, S. (1999). Risk of premenopausal breast cancer in association with occupational exposure to polycyclic aromatic hydrocarbons and benzene, Scandinavian Journal of Work, Environment and Health 25, 215-221.

Rundle, A., Tang, D., Hibshoosh, H., Estabrook, A., Schnabel, F., Cao, W., Grumet, S., and Perera, F. P. (2000). The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast cancer, Carcinogenesis 21, 1281-1289.

Srám, R. J., and Binková, B. (2000). Molecular epidemiology studies on occupational and environmental exposure to mutagens and carcinogens, 1997-1999, Environmental Health Perspectives 108(suppl 1), 57-70.

PAHs and Cancer Risk in Humans
   - Markers of Exposure to PAHs

ATSDR (1990). Toxicological profile for polycyclic aromatic hydrocarbons (Springfield, VA, Agency for Toxic Disease Substances Registry, National Technical Information Service).

Autrup, H., Daneshvar, B., Dragsted, L. O., Gamborg, M., Hansen, A. S., Loft, S., Okkels, H., Nielsen, F., Nielsen, P. S., Raffin, E., et al. (1999). Biomarkers for exposure to ambient air pollution-Comparison of carcinogen-DNA adduct levels with other exposure makers and makers of oxidative stress, Environmental Health Perspectives 107, 233-238.

Jacobson-Kram, D., Albertini, R. J., Branda, R. F., Falta, M. T., Iype, P. T., Kolodner, K., Liou, S., McDiarmid, M. A., Morris, M., Nicklas, J. A., et al. (1993). Measurement of chromosomal aberrations, sister chromatid exchange, hprt mutations, and DNA adducts in peripheral lymphocytes of human populations at increased risk for cancer, Environmental Health Perspectives 101, 121-125.

Jefcoate, C. R. (1998). Novel cytochrome P4501B1 as a mammary cancer risk factor (Fort Detrick, Maryland, U.S. Army Medical Research and Material Command).

Ralston, S. L., Coffing, S. L., Seidel, A., Luch, A., Platt, K., and Baird, W. M. (1997). Stereoselective activation of dibenzo[a,l]pyrene and its trans-11,12-dihydrodiol to Fjord region 11,12-diol 13,14-epoxides in a human mammary carcinoma MCF-7 cell-mediated V79 cell mutation assay, Chemical Research in Toxicology 10, 687-693.

Rundle, A., Tang, D., Hibshoosh, H., Estabrook, A., Schnabel, F., Cao, W., Grumet, S., and Perera, F. P. (2000). The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast cancer, Carcinogenesis 21, 1281-1289.

Srám, R. J., and Binková, B. (2000). Molecular epidemiology studies on occupational and environmental exposure to mutagens and carcinogens, 1997-1999, Environmental Health Perspectives 108(suppl 1), 57-70.

WHO (1998). Environmental Health Criteria 202, Selected Non-Heterocyclic Polycyclic Aromatic Hydrocarbons (Geneva, World Health Organization).

PAHs and Cancer Risk in Humans
   - Genetics and Polymorphism

Ambrosone, C. B., Freudenheim, J. L., Graham, S., Marshall, J. R., Vena, J. E., Brasure, J. R., Laughlin, R., Nemoto, T., Michalek, A. M., Harrington, A., et al. (1995). Cytochrome P4501A1 and glutathione S-transferase (M1) genetic polymorhisms and postmenopausal breast cancer risk, Cancer Research 55, 3483-3485.

Christou, M., Savas, Ü., Spink, D. C., Gierthy, J. F., and Jefcoate, C. R. (1994). Co- expression of human CYP1A1 and a human analog of cytochrome P450-EF in response tom 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7, Carcinogenesis 15, 725-732.

Coughlin, S. S., and Burke, W. (2000). Chapter 9, Public health assessment of genetic predisposition to cancer. In Genetics and Public Health in the 21st Century: Using Genetic Information to Improve Health and Prevent Disease, M. J. Khoury, W. Burke, and E. J. Thompson, eds. (http://www.cdc.gov/genetics/info/books/21stcent2b.htm3Chapter9,cited July 9, 2001, Oxford University Press).

Ishibe, N., Hankinson, S. E., Colditz, G. A., Spiegelman, D., Willett, W. C., Speizer, F. E., Kelsey, K. T., and Hunter, D. J. (1998). Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study, Cancer Research 58, 667-671.

Jefcoate, C. R. (1998). Novel cytochrome P4501B1 as a mammary cancer risk factor (Fort Detrick, Maryland, U.S. Army Medical Research and Material Command).

Jeffy, B. D., Schultz, E. U., Selmin, O., Gudas, J. M., and Bowden, G. T. (1999). Inhibition of BRCA-1 expression by benzo[a]pyrene and its diol epoxide, Molecular Carcinogenesis 26, 100-118.

Perera, F. P. (1997). Environment and cancer: Who are susceptible?, Science 278, 1068- 1073.

Raaka, S., Hassett, C., and Omeicinski, C. J. (1998). Human microsomal epoxide hydrolase: 5'-flanking region genetic polymorphisms, Carcinogenesis 19, 387-393.

Rundle, A., Tang, D., Hibshoosh, H., Estabrook, A., Schnabel, F., Cao, W., Grumet, S., and Perera, F. P. (2000). The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast cancer, Carcinogenesis 21, 1281-1289.

Srám, R. J., and Binková, B. (2000). Molecular epidemiology studies on occupational and environmental exposure to mutagens and carcinogens, 1997-1999, Environmental Health Perspectives 108(suppl 1), 57-70.

PAHs and Cancer Risk in Humans
  nbsp;- Estrogenicity and Estrogen Metabolism

Arcaro, K. F., O'Keefe, P. W., Yang, Y., Clayton, W., and Gierthy, J. F. (1999). Antiestrogenicity of environmental polycyclic aromatic hydrocarbons in human breast cancer cells, Toxicology 133, 115-127.

Chaloupka, K., Krishnan, V., and Safe, S. (1992). Polynuclear aromatic hydrocarbon carcinogens as antiestrogens in MCF-7 human breast cancer cells: role of the Ah receptor, Carcinogenesis 13, 2233-2239.

Charles, G. D., Bartels, M. J., Zacharewski, T. R., Gollapudi, B. B., Freshour, N. L., and Carney, E. W. (2000). Activity of benzo[a]pyrene and its hydroxylated metabolites in an estrogen recpetor-a reporter gene assay, Toxicological Sciences 55, 320-326.

Clemons, J. H., Allan, L. M., Marvin, C. H., Wu, Z., McCarry, B. E., Bryant, D. W., and Zacharewski, T. R. (1998). Evidence of estrogen- and TCDD-like activities in crude and fractionated extracts of PM10 air particulate material using in vitro gene expression assays, Environmental Science and Technology 32, 1853-1860.

PAH and Cancer Risk in Laboratory Animals

Arif, J. M., Smith, W. A., and Gupta, R. C. (1999). DNA adduct formation and persistence in rat tissues following exposure to the mammary carcinogen dibenzo[a,l]pyrene, Carcinogenesis 20, 1147-1150.

Cavalieri, E., Rogan, E., and Sinha, D. (1988). Carcinogenicity of aromatic hydrocarbons directly applied to rat mammary gland, Journal of Cancer Research and Clinical Oncology 114, 3-9.

Cavalieri, E. L., Higginbotham, S., RamaKrishna, N. V. S., Devanesan, P. D., Todorovic, R., Rogan, E. G., and Salmasi, S. (1991). Comparative dose-response tumorigenicity studies of dibenzo[a,l]pyrene versus 7,12-dimethylbenz[a]anthracene, benzo[a]pyrene and two dibenzo[a,l]pyrene dihydrodiols in mouse skin and rat mammary gland, Carcinogenesis 12, 1939-1944.

Russo, I. H., and Russo, J. (1996). Mammary gland neoplasia in long-term rodent studies, Environmental Health Perspectives 104, 938-967.

Thompson, H. J., and Singh, M. (2000). Rat models of premalignant disease, Journal of Mammary Gland Biology and Neoplasia 5, 409-420.

WHO (1998). Environmental Health Criteria 202, Selected Non-Heterocyclic Polycyclic Aromatic Hydrocarbons (Geneva, World Health Organization).

Sources of Human Exposure to PAHs

ATSDR (1990a). ATSDR Public Health Statement: Polycyclic Aromatic Hydrocarbons (http://www.atsdr.cdc.gov/ToxProfiles/phs9020.html, cited July 9, 2001, Agency for Toxic Disease Substances Registry).

ATSDR (1990b). Toxicological profile for polycyclic aromatic hydrocarbons (Springfield, VA, Agency for Toxic Disease Substances Registry, National Technical Information Service).

ATSDR (1996). ATSDR ToxFaqs: Polycyclic Aromatic Hydrocarbons (http://www.atsdr.cdc.gov/tfacts69.html, cited July 9, 2001, Agency for Toxic Substances Disease Registry).

Childers, J. W., Witherspoon, C. L., Smith, L. B., and Pleil, J. D. (2000). Real-time and integrated measurement of potential human exposure to particle-bound polycyclic aromatic hydrocarbons (PAHs) from aircraft exhaust, Environmental Health Perspectives 108, 853-862.

EPA (2000). Characterization of potential human health effects of diesel exhaust: hazard dose-response assessments. In Health Assessment Document for Diesel Exhaust (July 2000), EPA/600/8-90057E (http://www.epa.gov/ncea/dieslexh.htm, cited July 9, 2001, U.S. Environmental Protection Agency, National Center for Environmental Assesment).

Knize, M. G., Salmon, C. P., Pais, P., and Felton, J. S. (1999). Chapter 12, Food heating and the formation of heterocyclic aromatic amine and polycyclic aromatic hydrocarbon mutagens/carcinogens. In Advances in Experimental Medicine and Biology (New York, Kluwer Academic/Plenum Publishers), pp. 179-193.

Lewis, R. G., Fortune, C. R., Willis, R. D., Camann, D. E., and Antley, J. T. (1999). Distribution of pesticides and polycyclic aromatic hydrocarbons in house dust as a function of particle size, Environmental Health Perspectives 107, 721-726.

WHO (1998). Environmental Health Criteria 202, Selected Non-Heterocyclic Polycyclic Aromatic Hydrocarbons (Geneva, World Health Organization).

Environmental Fate of PAHs

ATSDR (1990). Toxicological profile for polycyclic aromatic hydrocarbons (Springfield, VA, Agency for Toxic Disease Substances Registry, National Technical Information Service).

WHO (1998). Environmental Health Criteria 202, Selected Non-Heterocyclic Polycyclic Aromatic Hydrocarbons (Geneva, World Health Organization).

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Prepared by Elizabeth Woodard, MD, MPH, BCERF Research Associate
and Suzanne Snedeker, PhD, BCERF Research Project Leader

We will make every effort to update this bibliography. If you have comments on this bibliography, or have a suggestion of a reference you would like us to review for inclusion in the bibliography, please send this information via email to: breastcancer@cornell.edu