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The BCERF program on the Cancer Risks of Environmental Chemicals in the Home and Workplace closed on March 31, 2010. No further updates will be made to this web site. Please go Cornell University’s eCommons web site to access BCERF’s archived research and educational materials (http://ecommons.library.cornell.edu/handle/1813/14300).

Breast Cancer and Pesticide Phosmet
Bibliography

This bibliography is provided as a service to our readers. It is compiled from the entries in the BCERF Environmental Risk Factors Bibliographic Database.

This bibliography is arranged topically. The topics include:


Review Articles

EPA. (1999). Frequently asked questions - phosmet ( http://www.epa.gov/pesticides/op/phosmet/phosfaq.htm: US Environmental Protection Agency), pp. 1-2.

EPA. (1998c). MEMO: Environmental fate and effects division RED chapter for phosmet (http://www.epa.gov/pesticides/op/phosmet.htm: US Environmental Protection Agency), pp. 1-57.

EPA. (1997a). MEMO: Phosmet [(mercaptomethyl) phthalimide S-(O, O-dimethylphosphorodithioate]: Hazard Identification Committee Report (http://www.epa.gov/pesticides/op/phosmet.htm: US Environmental Protection Agency - Office of Prevention, Pesticides, and Toxic Substances), pp. 1-10.

EPA. (1998b). MEMO: Phosmet: Acute and chronic dietary exposure and risk analyses for the HED RED (http://www.epa.gov/pesticides/op/phosmet.htm: US Environmental Protection Agency - Office of Prevention, Pesticides, and Toxic Substances), pp. 1-59.

EPA. (1998a). MEMO: Phosmet: HED human health risk assessment and supporting documentation for the reregistration eligibility decision document (RED) (http://www.epa.gov/pesticides/op/phosmet.htm: US Environmental Protection Agency - Office of Prevention, Pesticides, and Toxic Substances), pp. 1-20.

EPA. (1997b). MEMO: Toxicology chapter for Reregistration Eligibility Document (RED) on phosmet (http://www.epa.gov/pesticides/op/phosmet.htm: US Environmental Protection Agency), pp. 1-27.

EPA. (1986). Pesticide fact sheet number 101: phosmet (NTIS PB87-117198) (Washington, DC: EPA, Office of Pesticide Programs, Registration Division).

FAO/WHO. (1997). Evaluations of pesticide residues - 1997 (Phosmet) (http://www.fao.org/WAICENT/faoInfo/Agricult/Downloads/pes_alp.htm: Joint FAO/WHO Meeting on Pesticide Residues), pp. 687-733.

FAO/WHO. (1994). Pesticides Residues in Food -1994 (Phosmet). In Joint FAO/WHO Meeting on Pesticide Residues, pp. 119-135.

Cancer Risks in Phosmet-Exposed Humans

Brown, L. M., Blair, A., Gibson, R., Everett, G. D., Cantor, K. P., Schumann, L. M., Burmeister, L. F., Van Lier, S. F., and Dick, F. (1990). Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Research 50, 6585-6591.

Cantor, K. P., Blair, A., Everett, G., Gibson, R., Burmeister, L. F., Brown, L. M., Schumann, L., and Dick, F. R. (1992). Pesticides and other agricultural risk factors for non-Hodgkin's lymphoma among men in Iowa and Minnesota. Cancer Research 52, 2447-2455.

Experimental Animal Studies of Phosmet and Cancer

Chang, J., Morrissey, R., and Wyand, S. (1991). Unpublished report: 2-year toxicity/oncogenicity study with R-1504 in rats (Farmington, CT: Ciba-Geigy Corp.).

FAO/WHO. (1994). Pesticides Residues in Food -1994 (Phosmet). In Joint FAO/WHO Meeting on Pesticide Residues, pp. 119-135.

Katz, A., Sprague, G., Frank, J., Turnier, J., Zwicker, G., and Freudenthal, R. (1984). Unpublished report: two-year dietary oncogenicity study in mice with Imidan&trad; Technical (Farmington, CT: Stauffer Chemical Company).

Sprague, G., and Turnier, J. (1986). Unpublished study: addendum-two-year dietary oncogenicity study in mice with Imidan&trad; Technical. 1-5.

Mammary Cancer in Experimental Animals

Chang, J., Morrissey, R., and Wyand, S. (1991). Unpublished report: 2-year toxicity/oncogenicity study with R-1504 in rats (Farmington, CT: Ciba-Geigy Corp.).

Katz, A., Sprague, G., Frank, J., Turnier, J., Zwicker, G., and Freudenthal, R. (1984). Unpublished report: two-year dietary oncogenicity study in mice with Imidan&trad; Technical. (Farmington, CT: Stauffer Chemical Company).

Sprague, G., and Turnier, J. (1986). Unpublished study: addendum-two-year dietary oncogenicity study in mice with Imidan&trad; Technical. 1-5.

Tumor Promotion

Cabral, R., Hoshiya, T., Hakoi, K., Hasegawa, R., Fukushima, S., and Ito, N. (1991). A rapid in vivo bioassay for the carcinogenicity of pesticides. Tumori 77, 185-188.

Hasegawa, R., Cabral, R., Hoshiya, T., Hakoi, K., Ogiso, T., Boonyaphiphat, P., Shirai, T., and Ito, N. (1993). Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats. International Journal of Cancer 54, 489-493.

Mutagenicity and Genotoxicity

EPA. (1997b). MEMO: Toxicology chapter for Reregistration Eligibility Document (RED) on phosmet (http://www.epa.gov/pesticides/op/phosmet.htm: US Environmental Protection Agency), pp. 1-27.

FAO/WHO. (1994). Pesticides Residues in Food -1994 (Phosmet). In Joint FAO/WHO Meeting on Pesticide Residues, pp. 119-135.

Kiraly, J., Czeizel, A., and Szentesi, I. (1977). Genetic study on workers producing organophosphate insecticides. Mutation Research 46, 224.

Kiraly, J., Szentesi, I., Ruzicska, M., and Czeize, A. (1979). Chromosome studies in workers producing organophosphate insecticides. Archives of Environmental Contamination and Toxicology 8, 309-319.

Moriya, M., Ohta, T., Watanabe, K., Miyazawa, T., Kato, K., and Shirasu, Y. (1983). Further mutagenicity studies on pesticides in bacterial reversion assay systems. Mutation Research 116, 185-216.

Prevec, J. S., Okoampah, N. D., and Morton, R. A. (1992). Organophosphorus insecticide resistance in Drosophila melanogaster populations. Journal of Genetics 71, 121-134.

Purdy, M. (1998). High-dose exposure to systemic phosmet insecticide modifies the phosphatidylinositol anchor on the prion protein: the origins of new variant transmissible spongiform encephalopathies? Medical Hypotheses 50, 91-111.

Purdy, M. (1996). The UK-epidemic of BSE: slow virus or chronic pesticide-initiated modification of the prion protein? Medical Hypotheses 46, 445-454.

Shirasu, Y., Moriya, M., Kato, K., Furuhashi, A., and Kada, T. (1976). Mutagenicity screening of pesticides in the microbial system. Mutation Research 40, 19-30.

Slamenova, D., Dusinska, M., Gabelova, A., Bohusova, T., and Ruppaova, K. (1992). Decemtione (Imidan)-induced single-strand breaks to human DNA, mutations at the hgprt locus of V79 cells, and morphological transformations of embryo cells. Environmental and Molecular Mutagenesis 20, 73-78.

Vlckova, V., Miadokova, E., Podstavkova, S., and Vlcek, D. (1993). Mutagenic activity of phosmet, the active component of the organophosphorus insecticide Decemtion EK 20 in Salmonella and Saccharomyces assays. Mutation Research 302,153-156.

Reproductive Toxicity

Ackermann, H. (1974). Transfer of organophosphorous inseticides to the embryo-formation of PO derivatives and development of toxic symptoms. Tagungsbericht Akademie der Landwirtschaftswissenschaften DDR 126, 23-29.

Culliney, T. W., Pimentel, D., and Pimentel, M. H. (1992). Pesticides and natural toxicants in foods. Agriculture, Ecosystems and Environment 41, 297-300.

EPA. (1997b). MEMO: Toxicology chapter for Reregistration Eligibility Document (RED) on phosmet (http://www.epa.gov/pesticides/op/phosmet.htm: US Environmental Protection Agency), pp. 1-27.

Fabro, S., Smith, R., and Williams, R. (1966). Embryonic activity of some pesticides and drugs related to phtalimide. Food and Cosmetics Toxicology 3, 587-590.

FAO/WHO. (1994). Pesticides Residues in Food -1994 (Phosmet). In Joint FAO/WHO Meeting on Pesticide Residues, pp. 119-135.

Kundiev, Y. I., Karakashyan, A. M., and Chusova, V. N. (1993). Effects of pesticides and other adverse factors in agriculture on the female reproductive system (an epidemiological study). In Reproductive Toxicology, M. Richardson, ed. (Weinheim: VCH), pp. 155-166.

Martson, L. V., and Voronina, V. M. (1976). Experimental study of the effect of a series of phosphoroorganic pesticides (Dipterex and Imidan) on embryogenesis. Environmental Health Perspectives 13, 121-125.

Nicolson, T. B., Nettleton, P. F., Spence, J. A., and Calder, K. H. (1985). High incidence of abortions and congenital deformities of unknown aetiology in a beef herd. The Veterinary Record 116, 281-284.

Quinto, I., De Marinis, E., Mallardo, M., Arcucci, A., Della Morte, R., and Staiano, N. (1989). Effect of DNOC, Ferbam and Imidan exposure on mouse sperm morphology. Mutation Research 224, 405-408.

Staples, R. E., Kellam, R. G., and Haseman, J. K. (1976). Developmental toxicity in the rat after ingestion or gavage of organophosphate pesticides (Dpiterex, Imidan) during pregnancy. Environmental Health Perspectives 13, 133-140.

Hormone Disruption and Estrogenicity

Quinto, I., De Marinis, E., Mallardo, M., Arcucci, A., Della Morte, R., and Staiano, N. (1989). Effect of DNOC, Ferbam and Imidan exposure on mouse sperm morphology. Mutatation Research 224, 405-408.

Vargova, M., Gajdova, M., Jakubovsky, J., and Wsolova, L. (1994). Estrogenic effects of some xenobiotics. Archives of Toxicology Supplement 17, 148-152.

Immunotoxic Effects

Frank, A. A., Ross, J. L., and Sawvell, B. K. (1992). Toxic epidermal necrolysis associated with flea dips. Veterinary and Human Toxicology 34, 57-61.

Occupational Exposure

EPA. (1997a). MEMO: Phosmet [(mercaptomethyl) phthalimide S-(O, O-dimethylphosphorodithioate]: Hazard Identification Committee Report (http://www.epa.gov/pesticides/op/phosmet.htm: US Environmental Protection Agency - Office of Prevention, Pesticides, and Toxic Substances), pp. 1-10.

EPA. (1998a). MEMO: Phosmet: HED human health risk assessment and supporting documentation for the reregistration eligibility decision document (RED) (http://www.epa.gov/pesticides/op/phosmet.htm: US Environmental Protection Agency - Office of Prevention, Pesticides, and Toxic Substances), pp. 1-20.

Kahn, E. (1980). Epidemiology of field re-entry poisoning. Journal of Environmental Pathology and Toxicology 4, 323-330.

Kiraly, J., Czeizel, A., and Szentesi, I. (1977). Genetic study on workers producing organophosphate insecticides. Mutation Research 46, 224.

Kiraly, J., Szentesi, I., Ruzicska, M., and Czeize, A. (1979). Chromosome studies in workers producing organophosphate insecticides. Archives of Environmental Contamination and Toxicology 8, 309-319.

Kundiev, Y. I., Karakashyan, A. M., and Chusova, V. N. (1993). Effects of pesticides and other adverse factors in agriculture on the female reproductive system (an epidemiological study). In Reproductive Toxicology, M. Richardson, ed. (Weinheim: VCH), pp. 155-166.

Loewenherz, C., Fenske, R. A., Simcox, N. J., Bellamy, G., and Kalman, D. (1997). Biological monitoring of organophosphorus pesticide exposure among children of agricultural workers in central Washington state. Environmental Health Perspectives 105, 1344-1353.

MacNeil, J. D., and Hikichi, M. (1986). Phosmet residues in an orchard and adjacent recreational area. Journal of Environmental Science and Health B21, 375-385.

Maddy, K. (1976). Current considerations on the relative importance of conducting additional studies on hazards of field worker exposure to pesticide residues as compared to studying other occupational safety hazards on the farm. In Pesticide Residue Hazards to Farm Workers (Salt Lake City, UT: National Institute for Occupational Safety and Health), pp. 125-142.

Rosenberg, J., and Quenon, S. (1988). Organophosphate toxicity associated with flea-dip products-California. Journal of American Medical Association 260, 22-23.

Stokes, L., Stark, a., Marshall, E., and Narang, A. (1995). Neurotoxicity among pesticide applicators exposed to organophosphates. Occupational and Environmental Medicine 52, 648-653.

Potential of Exposure for the General Population

Bradman, M. A., Harnly, M. E., Draper, W., Seidel, S., Teran, S., Wakeham, D., and Neutra, R. (1997). Pesticide exposures to children from California's Central Valley: results of a pilot study. Journal of Exposure Analysis and Environmental Epidemiology 7, 217-234.

EPA. (1999). Frequently asked questions - phosmet (http://www.epa.gov/pesticides/op/phosmet/phosfaq.htm: US Environmental Protection Agency), pp. 1-2.

EPA. (1998c). MEMO: Environmental fate and effects division RED chapter for phosmet (http://www.epa.gov/pesticides/op/phosmet.htm: US Environmental Protection Agency), pp. 1-57.

EPA. (1998b). MEMO: Phosmet: Acute and chronic dietary exposure and risk analyses for the HED RED (http://www.epa.gov/pesticides/op/phosmet.htm: US Environmental Protection Agency - Office of Prevention, Pesticides, and Toxic Substances), pp. 1-59.

EPA. (1998a). MEMO: Phosmet: HED human health risk assessment and supporting documentation for the reregistration eligibility decision document (RED) (http://www.epa.gov/pesticides/op/phosmet.htm: US Environmental Protection Agency - Office of Prevention, Pesticides, and Toxic Substances), pp. 1-20.

FAO/WHO. (1997). Evaluations of pesticide residues - 1997 (Phosmet) (http://www.fao.org/WAICENT/faoInfo/Agricult/pes_alp.htm: Joint FAO/WHO Meeting on Pesticide Residues), pp. 687-733.

Loewenherz, C., Fenske, R. A., Simcox, N. J., Bellamy, G., and Kalman, D. (1997). Biological monitoring of organophosphorus pesticide exposure among children of agricultural workers in central Washington state. Environmental Health Perspectives 105, 1344-1353.

Simcox, N. J., Fenske, R. A., Wolz, S. A., Lee, I., and Kalman, D. A. (1995). Pesticides in household dust and soil: exposure pathways for children of agricultural families. Environmental Health Perspectives 103,1126-1134.

Storage and Excretion of Phosmet in Mammals

Ackermann, H., Seidler, H., Kagan, Y. S., and Voronina, V. M. (1976). Metabolic and toxic behavior of phthalimide derivates. Archives of Toxicology 36, 127-137.

Ford, I., Menn, J., and Meyding, G. (1966). Metabolism of N-(mercaptomethyl)-phthalimide-carbonyl-C14-(S-(O,O-dimethyl-phosphorodithioate)(imidan-C14)): balance study in the rat. Journal of Agricultural and Food Chemistry 14, 83-86.

Johnson, J., and Bowman, M. (1968). Fate of bidrin and imidan when fed in silage to lactating dairy cows. Journal of Dairy Science 51, 1225-1228.

McBain, J., Menn, J., and Casida, J. (1968). Metabolism of carbonyl-C14 - labeled Imidan, N-(mercaptomehtyl)phtalimide-S-(O)-dimethyl-phosphorodithioate in rats and cockroaches. Journal of Agricultural and Food Chemistry 16, 813-820.

Mount, M. E. (1984). Comparison of measurement of dialkyl phosphates in milk/urine and blood cholinesterase and insecticide concentrations in goats exposed to the organophosphate insecticide, Imidan. Toxicology and Applied Pharmacology 72, 236-244.

O'Keefe, M., Eades, J. F., and Strickland, K. L. (1983). Phosmet residues in milk following treatment of dairy cows for warble-fly. Journal of the Science of Food and Agriculture 34, 463- 465.

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Prepared by Saemi Mathews, Research Assistant, and
Renu Gandhi, Ph.D., Research Associate, BCERF

We will make every effort to update this bibliography. If you have comments on this bibliography, or have a suggestion of a reference you would like us to review for inclusion in the bibliography, please send this information via email to: breastcancer@cornell.edu